Unlock Assignment Ada Mini-game:
Beat the game to unlock the mini game
Unlock Hunk in Mercenaries:
Get a 4 star rating on the Island Commando map of the game.
Unlock Ada Wong in Mercenaries:
Get a 4 star rating on the Pueblo map of the game.

Unlock Albert Wesker in Mercenaries:
Get a 4 star rating on the Waterworld map of the game.

Unlock Jack Krauser in Mercenaries:
Get a 4 star rating on the Castle map of the game.
Unlock Matilda Weapon (which fires 3 round bursts):
Successfully clear the game.
Unlock Hand Cannon Weapon:
Get the five star ranking on the mercenaries mini-game.

Unlock Rocket Launcher:
Beat the game on Normal and you get a chance too buy the Matilda ($70,000) and the Infinite Launcher ($1,000,000).
Unlock S.T.A.R.S. Uniform:
Complete The Game On Normal Or Hard Mode.