There is a bit of a glitch in the game that will allow you to take out and/or knock down 4-5 ganados without taking damage even if you get hit. When you have a pack of 3-5 normal enemies coming at you, take a look at their position. If one is slightly ahead of the rest, you should be able to pull off this trick. Shoot the leader in the head. If it's head doesn't explode, run up to it and kick. If you time it right, you will take out the group of enemies with a single kick. (Leons kick has firepower of 5.0) Also, the kick animation overrides enemy attacks, so even if you are hit, you don't take damage. This is a good way of dealing with closely bunched enemies w/out using shotgun ammo or grenades.