| Unlockable: | How to unlock: |
| Alive Without Breath | You took possession of a fish |
| An Unfortunate Accident | You killed Morgan Pendleton with steam |
| Art Dealer | Collect all the Sokolov paintings |
| Back Home | Grab a live grenade and use it to kill an attacker |
| Big Boy | Kill a tallboy with only your sword |
| Bodyguard | You protected Callista's uncle, Captain Geoff Curnow |
| Capturing Genius and Madness | Complete the Bridge mission |
| Child Care | Find Emily Kaldwin |
| Clean Hands | Complete the game without killing anyone |
| Cleaner | Fight with 5 enemies at once, without any of them surviving |
| Creepy Crawly | You used a rat tunnel |
| Dishonored | Complete the Intro missions |
| Dunwall in Chaos | You completed the game in high chaos |
| Excommunication | Eliminate High Overseer Campbell |
| Faceless | After escaping Coldridge Prison, complete a single mission without alerting anyone |
| Food Chain | You assassinated an assassin |
| Gentleman Caller | You completed all the Granny Rags side missions |
| Ghost | Complete all missions after the prologue, alerting no one or killing no one but key targets |
| Harm's Way | Cause 5 unintentional suicides |
| Hornets' Nest | Kill 4 enemies in less than 1 second using the crossbow |
| Inhabitant | Stay in possession of others for most of a 3 minute period |
| Just Dark Enough | You completed the game in low chaos |
| King of the World | You reached the top of Kaldwin's Bridge |
| Lights Out | You deactivated at least 5 security systems on Kingsparrow Island |
| Long Live the Empress | You saved Empress Emily Kaldwin |
| Manipulator | Make others kill 5 of their own allies |
| Merchant of Disorder | Acquire 15 equipment upgrades |
| Mercy is the Mark | You spared Daud’s life |
| Mostly Flesh and Steel | Finish the game without purchasing any supernatural powers or enhancements, besides Blink |
| Occultist | Collect 10 bone charms |
| Poetic Justice | You neutralized all key targets using indirect means |
| Political Suicide | Expose the Lord Regent's crimes and bring about his arrest |
| Razor Rain | Kill 5 characters with Drop Assassination |
| Regicide | Assassinate the Lord Regent, Hiram Burrows |
| Resolution | Complete the game |
| Rogue | Assassinate 10 unaware enemies |
| Shadow | Complete all missions after the prologue without alerting anyone |
| Specter | After escaping prison, complete a mission without alerting anyone, and kill less than 5 people |
| Speed of Darkness | Travel 30 meters in less than 1 second |
| Street Conspiracy | You completed all the Slackjaw side missions |
| Surgical | Play from the first mission through Kaldwin's Bridge killing fewer than 10 characters |
| Tempest | Kill 6 enemies in less than 1 second |
| The Art of the Steal | You got the Art Dealer's safe combination for Slackjaw, but robbed the safe first |
| The Escapist | After Coldridge Prison, elude 5 pursuers at once without killing them or leaving the map |
| Thief | Pickpocket items worth a total of 200 coins |
| This Is Mine | Recover your belongings |
| Vanished | You escaped prison and navigated the sewers undetected |
| Versatile | Kill characters with each weapon and offensive gadget |
| Wall of Sparks | Kill an enemy using a Wall of Light |
| Well Mannered | You completed the Boyle Estate mission without spoiling the party |
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