| Unlockable: | How to unlock: |
| A man with guts and honor | Reach the end of the descent on Mission 6 having killed all of the enemies |
| Absolutely crazy about it | Spend 50,000 Red Orbs |
| And welcome to Hell! | Complete all missions on the Hell and Hell difficulty |
| And you are set free | Free half of the Lost Souls |
| Bring it on! | Slay 1,000 Demons |
| Cleaning up his Dad's mess | Defeat Mundus |
| Come on Puppy. Let's go! | Defeat your pursuer |
| Devils never cry | Complete all missions on the Dante Must Die difficulty |
| Dude, the show's over! | Find all of the Keys |
| Every hero has a weakness | Complete Furnace of Souls without taking damage from the furnace |
| Fill your dark soul with light | Free all of the Lost Souls |
| Flock off, feather-face! | Survive the encounter with the Tyrant |
| For Tony Redgrave | Kill 50 enemies using nothing but firearms |
| He's a demon too | Help Phineas retrieve his eye |
| I need more power! | Complete Vergil's downfall on Son of Sparda difficulty |
| I'll try it your way for once | Complete all missions in Vergil's downfall on the Nephilim difficulty with a SSS rank |
| I've come to retrieve my power | Acquire all of Vergil's health, Devil trigger and combat upgrades |
| Impressive | Slay 100 Demons |
| In the name of my father | Kill 100 enemies using nothing but Demon weapons |
| It's got to stay in the family | Acquire Arbiter |
| It's only the rain | Kill 10 enemies by pushing them into the Hurricane ride on Mission 1 |
| It's showtime. Come on! | Earn 1,500 Style Bonuses |
| It's time to finish this! | Help Vergil open the Vault |
| Jackpot! | Complete all missions on the Nephilim difficulty with a SSS rank |
| Keeps getting better and better | Gain a 100% completion rank on all missions (difficulty doesn't matter) |
| Let's rock, baby! | Upgrade Dante's health to maximum |
| Let's welcome chaos! | Open all of the Secret Doors |
| Looks like it's your lucky day | Complete a level without taking any damage |
| Looks like we have a winner | Slay 5,000 Demons |
| Might controls everything | Gain a 100% completion rank on all missions in Vergil's downfall (difficulty doesn't matter) |
| More than just a few sparks | Acquire Revenant |
| No talking! | Acquire Aquila |
| Now I'm a little motivated! | Complete Vergil's downfall on Heaven or Hell difficulty |
| Now my coat's all charred | Navigate the Sky Bridge on Mission 16 without hitting the lasers |
| One hell of a party! | Complete all of the Secret Missions |
| Only kind of gift worth giving | Acquire the Angel Boost ability |
| Our souls are at odds brother | Complete Vergil's downfall |
| Power... Give me more power! | Purchase all of Dante's combat upgrades |
| Sensational! | Gain a SSS Style Rank during combat |
| Stylish! | Complete a mission with a SSS rank |
| The end? Don't bet on it | Complete the final mission on Human, Devil Hunter or Nephilim difficulty |
| Thing drives me crazy | Acquire Osiris |
| This baby sure can pack a punch | Acquire Eryx |
| This is my kind of rain | Spend 10,000 Red Orbs |
| This is the power of Sparda! | Complete Vergil's downfall on Vergil Must Die difficulty |
| This is what I live for! | Complete all missions on the Heaven or Hell difficulty |
| This party's just getting crazy! | Complete 10 Secret Missions |
| Time to go to work guys! | Purchase your first upgrade |
| Too easy! | Complete all missions on the Son of Sparda difficulty |
| We have an uninvited guest | Defeat a Wisp |
| Whatever, Lady | Defeat Mundus' spawn |
| Where does the time go? | Complete a level with 2 minutes or less on the clock |
| You are not a Human, are you? | Acquire the Devil Trigger ability |
| You can't handle it | Upgrade Dante's Devil Trigger to maximum |
| You don't belong here | Defeat an Imprisoner |
| You'll never have her fire | Kill 100 enemies using nothing but Angel weapons |
| You're not going to shoot me | Acquire Kablooey |
| You're not worthy as my opponent | Complete Vergil's downfall on Hell and Hell difficulty |
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