The game is completely randomized to the point that you should save
constantly esp after you locate a family member to save. If you don't
and you die, when you go back to that room to save them they will most
likely not be there but somewhere else. A good idea if this happens is
to reload the last start point and keep going back to that room
.Reloading each time.  On average every third time or so they will
reappear so don't stress to much.