| Unlockable: | How to unlock: |
| Ace of Bass | Complete all Bass Technique Challenges to Gold |
| All Rounder | Beat 100,000 points in a Combo Arrangement |
| All your bass | Collect all basses |
| Art + Functionality | Collect all guitars |
| Bass Camp | Play a bass arrangement |
| Bass Face | Beat 100,000 points in a Bass arrangement |
| Bass Head | Collect all bass gear |
| Bass-Box | Earn a bass pedal, amp, or cabinet |
| Batter Up | Play the Guitarcade game: Big Swing Baseball |
| Beat Harmonics | Beat 1,000,000 points in the Guitarcade game: Harmonically Challenged |
| Beneficial Friends | Play multiplayer with 2 guitars |
| Better Than An Encore? | Play a Double Encore |
| Cente-beater | Beat a 100 Note Streak |
| Challenge Harmonics | Play the Guitarcade game: Harmonically Challenged |
| Chordinated | Beat 100,000 points in a Chord Arrangement |
| D-licious | Use the Tuner to tune to Drop-D |
| Databass | Play a song with emulated bass using a guitar |
| Duck Hunter | Play the Guitarcade game: Ducks |
| Ducks x 6 | Play the Guitarcade game: Super Ducks |
| Elite Guitarist | Reach Rank 9 |
| Fret Fast | Beat 10,000,000 points in the Guitarcade game: Ducks |
| Furious Plucker | Beat 5,000,000 points in the Guitarcade game: Quick Pick Dash |
| Giant! | Beat 2,000,000 points in the Guitarcade game: Big Swing Baseball |
| Guitardead | Beat 1,000,000 points in the Guitarcade game: Dawn of the Chordead |
| Half K | Beat a 500 Note Streak |
| Happy Shopper | Visit the Shop |
| Hear Me Now | Use the Amp |
| International Headliner | Reach Rank 8 |
| International Support Act | Reach Rank 7 |
| Just Awesome | Beat a 750 Note Streak |
| Just Singing? | Using a mic, sing along and achieve Good Singing |
| Just Super! | Beat 150,000,000 points in the Guitarcade game: Super Ducks |
| Local Headliner | Reach Rank 4 |
| Local Support Act | Reach Rank 3 |
| My 1st Encore | Play an Encore |
| My 1st Gig | Play an Event |
| National Headliner | Reach Rank 6 |
| National Support Act | Reach Rank 5 |
| New Act | Reach Rank 2 |
| No Dischord | Beat a 25 Chord Streak |
| OK, I Learned | Beat 200,000 points in Master Mode |
| Rocksmith | Reach Rank 11 |
| Rumblesmith | Reach rank 11 on Bass |
| Scales Owned | Beat 50,000,000 points in the Guitarcade game: Scale Runner |
| Singles Rock | Beat 100,000 points in a Single Note Arrangement |
| Slide Puzzle | Play the Guitarcade game: Super Slider |
| Slide to Victory | Beat 15,000,000 points in the Guitarcade game: Super Slider |
| Solo Foundations | Play the Guitarcade game: Scale Runner |
| Stage Ready | Complete a Master Event |
| Strummer | Beat a 5 Chord Streak |
| Super Elite Guitarist | Reach Rank 10 |
| The Basics | Complete Soundcheck (Reach Rank 1) |
| The Bassics | Complete all Bass Technique Challenges to Bronze |
| The Bottom Line | Complete a bass event |
| The One With Zombies | Play the Guitarcade game: Dawn of the Chordead |
| The Rocksmith Method | Complete all Technique Challenges to Bronze |
| Tone is my Avatar | Create and save a custom tone |
| Tone Peddler | Collect 50 effects pedals |
| Tutorials My Ax | Complete all Technique Challenges to Gold |
| Where Rainbows Come From | Play the Guitarcade game: Quick Pick Dash |
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