There are a few options that are available on the right
hand side of the screen during game play. Simply select the "Guides"
option, then choose "Suggestions". A box with a list
of all the possible words you can play with your letters from
highest to lowest will appear. To play the word, simply double
click on the word of your choice on the list and it will be displayed
on the game board. Then, click "Play". You will win
almost all of the time under any difficulty setting against any
number of players (including CPU opponents).