There are 34 Bronze Trophies, 15 Silver Trophies, 1 Gold Trophy, and 1 Platinum Trophy.
| Unlockable: | How to unlock: |
| A Real Pistol | Killed 25 enemies with the Broadsider Pistol. |
| Bronze |
| Aerial Assassin | Killed 20 enemies with a Sky-Line Strike. |
| Bronze |
| Armed Revolt | Assisted the gunsmith. |
| Bronze |
| Auld Lang Syne | Completed the game on 1999 Mode. |
| Silver |
| Big Game Hunter | Killed 100 enemies with the Founder Huntsman Carbine or Vox Burstgun. |
| Bronze |
| Blood in the Streets | Completed Emporia. |
| Bronze |
| Bolt From the Blue | Killed 5 enemies with a headshot while riding a Sky-Line. |
| Silver |
| Bon Voyage | Killed 20 enemies by knocking them off Columbia. |
| Silver |
| Coins in the Cushion | Looted 200 containers. |
| Silver |
| Combination Shock | Performed all 8 of the Vigor combinations. |
| Silver |
| David & Goliath | Killed 20 "Heavy Hitter" enemies. |
| Bronze |
| Dress for Success | Equipped a piece of Gear in all four slots. |
| Silver |
| Eavesdropper | Collected every Voxophone. |
| Silver |
| First Class Ticket | Boarded The First Lady. |
| Bronze |
| Grand Largesse | Spent $10,000 at the vending machines of Columbia. |
| Bronze |
| Hazard Pay | Killed 10 enemies by utilizing environmental hazards. |
| Silver |
| Heartbreaker | Killed a Handyman by only shooting his heart. |
| Bronze |
| Here Little Piggy | Killed 30 enemies with the Founder Pig Volley Gun or Vox Hail Fire. |
| Bronze |
| Higher Learning | Completed Comstock House. |
| Bronze |
| Industrial Accident | Killed 20 enemies with a Sky-Hook Execution. |
| Bronze |
| Infused with Greatness | Collected every Infusion upgrade in a single game. |
| Bronze |
| Kitted Out | Fully upgraded one weapon and one Vigor. |
| Bronze |
| Loose Cannon | Killed 25 enemies with the Paddywhacker Hand Cannon. |
| Bronze |
| Lost Weekend | Killed 5 enemies while you are drunk. |
| Silver |
| Master of Pyrotechnics | Killed 20 enemies with the Barnstormer RPG. |
| Bronze |
| Mind Over Matter | Killed 20 enemies using Possessed machines. |
| Silver |
| More for Your Money | Lured 3 enemies into a single Vigor trap 5 times. |
| Silver |
| On a Clear Day... | Killed 30 enemies with the Bird's Eye Sniper Rifle. |
| Bronze |
| On the Fly | Killed 30 enemies while riding a Sky-Line. |
| Bronze |
| Passionately Reciprocated | Killed 150 enemies with the Founder Triple R Machine Gun or Vox Repeater. |
| Bronze |
| Platinum Columbia | Acquire all other trophies |
| Platinum |
| Raising the Bar | Upgraded one attribute (Health, Shield, or Salts) to its maximum level. |
| Bronze |
| Saw the Elephant | Completed the game on Normal difficulty or above. |
| Bronze |
| Scavenger Hunt | Completed the game in 1999 Mode without purchasing anything from a Dollar Bill machine. |
| Gold |
| Seasoned to Taste | Killed 30 enemies with the Peppermill Crank Gun. |
| Bronze |
| Shock Tactics | Retrieved Shock Jockey. |
| Bronze |
| Should Auld Acquaintance... | Unlocked 1999 Mode. |
| Bronze |
| Sightseer | Used all telescopes and Kinetoscopes in the game. |
| Bronze |
| Skeet Shoot | Killed 5 enemies while they are falling. |
| Silver |
| Stone Cold Pinkerton | Completed the game on Hard difficulty or above. |
| Silver |
| Strange Bedfellows | Killed 20 enemies using allies brought in through a Tear. |
| Silver |
| Street Sweeper | Killed 50 enemies with the Founder China Broom Shotgun or Vox Heater. |
| Bronze |
| Tear 'em a New One | Opened 30 Tears. |
| Bronze |
| The Bird or The Cage | Completed The Hand of the Prophet. |
| Bronze |
| The Roguish Type | Used Elizabeth to pick 30 locks. |
| Silver |
| Tin Soldier | Completed the game on Easy difficulty or above. |
| Bronze |
| Vigorous Opposition | Killed 75 enemies either with a Vigor or while the enemy is under the effects of a Vigor. |
| Bronze |
| Welcome to Monument Island | Reached Monument Island. |
| Bronze |
| Well Rounded | Used all 8 Vigors against enemies. |
| Bronze |
| Working Class Hero | Completed the Factory. |
| Bronze |
| Written in the Clouds | Completed Lighthouse. |
