There are 42 Bronze Trophies, 5 Silver Trophies, 3 Gold Trophies, and 1 Platinum Trophy.
| Unlockable: | How to unlock: |
| "Yes!" (Bronze) | Activate Ben's synergy assist |
| A great Big Hug (Bronze) | Activate Bubbles' synergy assist |
| Adventure! (Bronze) | Win the first Flapjack Pier level in story mode with Flapjack and K'nuckles in under three minutes |
| AH-ha-ha! AH-ha-HA ha-ha! (Bronze) | Activate Mandark's assist while fighting against Dexter |
| Ben 10 Fan (Bronze) | Finish the Ben 10 theme in story mode |
| Big Money! (Silver) | Collect 1000 points from a single level |
| Billy & Mandy Fan (Bronze) | Finish the Grim Adventure's theme in story mode |
| Cartoon Collector (Gold) | Unlock all characters |
| Chicken Ball Z (Bronze) | Score four knockouts after using Billy and Mandy's PTE |
| Chowder Fan (Bronze) | Finish the Chowder theme in story mode |
| Costume Collector (Gold) | Unlock all costumes |
| Couch Potato (Silver) | Beat Story Mode |
| Dexo Robo 2000 (Bronze) | Score two knockouts using Dexter's PTE |
| Dexter's Lab Fan (Bronze) | Finish the Dexter's Lab theme in story mode |
| Dial M for Monkey (Bronze) | Win ten fights as Monkey in his alternate costume |
| Disco Fever (Bronze) | Score two consecutive knockouts using Captain Planet's synergy assist |
| Do the Monkey (Bronze) | Activate Johnny's synergy assist |
| Father is Number One (Bronze) | Win five fights as Father with Numbuh One as an opponent |
| Flame Broiled (Bronze) | Score a knockout using Father's synergy assis |
| Flapjack Fan (Bronze) | Finish the Flapjack theme in story mode |
| Flushed (Bronze) | Score two simultaneous knockouts using Toiletnator's PTE |
| Foster's Fan (Bronze) | Finished the Foster's Home theme in story mode |
| Freedom!!! (Bronze) | Win the Toadblatt's level in story mode with Grim in under two minutes |
| Frenemies (Bronze) | Defeat Kevin boss using Ben without dying |
| Go Mac Go (Bronze) | Win ten fights as Mac and Bloo in their alternate costumes |
| Him Diddle Riddle (Bronze) | Win ten fights as Him against a Powerpuff girl |
| I am not your Boyfriend (Bronze) | Activate Panini's assist while fighting against Chowder |
| It's Hero Time! (Bronze) | Win the Bellwood fight in story mode with Ben or Young Ben in under a minute |
| It's over 9000! (Silver) | Collect 9001 points |
| KND Fan (Bronze) | Finish the KND theme in story mode |
| Like a Hoss (Bronze) | Win the Endsville Cemetery level in story mode with Hoss Delgado without dying |
| Master of Darkness (Bronze) | Win five fights as Aku with Jack as an opponent |
| Meet My Beautiful Wife (Bronze) | Activate Scotsman's PTE and Peppermint Larry's Assist in the same fight |
| Ninjas Beat Pirates (Bronze) | Win a fight as Jack in his alternate costume with Flapjack and K'nuckles as opponents |
| No Big Deal (Silver) | Beat Story Mode on the Hard difficulty setting |
| Not Powerpuff, Rowdyruff! (Bronze) | Win a fight with each Powerpuff in alternate costume against a Powerpuff in normal outfit |
| P90 Him (Bronze) | Win nine fights as Him in his alternate costume |
| Planet of the Ape (Bronze) | Win ten fights as Mojo Jojo against a Powerpuff girl |
| PPG Fan (Bronze) | Finish the Powerpuff Girls theme in story mode |
| Professional Hero (Silver) | Defeat the Final boss without dying |
| Punchtime Explosion Pro (Platinum) | Earn all trophies |
| S.E.C.T.O.R. V. (Bronze) | Complete Kids Next Door Platforming in under five minutes |
| Samurai Jack Fan (Bronze) | Finish the Samurai Jack theme in story mode |
| Samurai's Journey (Bronze) | Defeat Aku boss using Jack without dying |
| The power is yours! (Bronze) | Score three simultaneous knockouts using Captain Planet's PTE |
| Ugly Finish (Bronze) | Score four consecutive knockouts using Kevin's PTE |
| Unreal Estate Collector (Gold) | Unlock all arenas |
| Vengeance of Vilgax (Bronze) | Win five fights as Vilgax against Ben and Young Ben |
| Viking God of Rock (Bronze) | Score two consecutive knockouts with Aku's synergy assist |
| Way of the Samurai (Bronze) | Score five knockouts after activating Jack's PTE |
| What Does This Button Do? (Bronze) | Activate DeeDee's assist while fighting against Dexter |
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