There are 41 Bronze Trophies, 7 Silver Trophies, 2 Gold Trophies, and 1 Platinum Trophy.
| Unlockable: | How to unlock: |
| Aliens (Bronze) | Collect all Alien Artifacts. |
| And Then We Doubled It! (Bronze) | Dismember 1000 limbs from living enemies. |
| Architect (Bronze) | Share a Blueprint with your Co-Op partner. |
| Aren't You Thankful? (Gold) | Complete the game on Hardcore Mode. |
| Axes High (Bronze) | Kill 30 enemies using Fodder axes. |
| Blast Corps (Bronze) | Kill 30 enemies with explosion damage. |
| Brave New World (Platinum) | Obtain all trophies. |
| Circuit's Edge (Bronze) | Add a Circuit to a Weapon. |
| Close Encounter (Bronze) | Kill 10 alien Necromorphs. |
| Critical Mass (Bronze) | Recover the shuttle. |
| Drill Sergeant (Bronze) | Complete the Drill Room without taking any damage. |
| Dropping Acid (Bronze) | Dissolve 50 enemies with acid. |
| Electric Lawnmower (Bronze) | Kill 30 enemies using an electrified Ripper blade. |
| Empty Chamber (Bronze) | Kill 30 enemies using melee strikes or a melee Weapon Part. |
| EMT (Bronze) | Craft a Large Med Pack. |
| Epic Tier 4 Engineer (Silver) | Complete the game in Classic Mode. |
| From the Jaws (Bronze) | Save your Co-Op partner from an execution by killing the attacker. |
| Full House (Bronze) | Craft a Weapon with 2 Tools, Tips, and Attachments with all Circuit slots filled. |
| Get On My Level (Bronze) | Complete the game on any difficulty setting. |
| Ghosts of the Past (Silver) | Face all of Carver's demons by completing all Co-Op only optional missions. |
| Go for the Limbs! (Bronze) | Dismember 500 limbs from living enemies. |
| Gun Collector (Bronze) | Collect all Weapon Parts. |
| Hungry (Bronze) | Reach the pump room of the Waystation without alerting any Feeders. |
| Hydra (Bronze) | Kill the Snowbeast. |
| Infernal Machine (Bronze) | Reach the Alien Machine. |
| Intestinal Fortitude (Silver) | Defeat the Hive Mind. |
| Master Plan (Bronze) | Create a Blueprint that needs at least 2000 resources worth of parts and Circuits to build. |
| Medic! (Bronze) | Revive your Co-Op partner 10 times. |
| Metal Detector (Bronze) | Successfully deploy Scavenger Bots to 15 Resource Areas. |
| My Buddy (Bronze) | Retrieve Resources from a Scavenger Bot at a Bench. |
| Overpowered Healing (Bronze) | Use quick heal to heal yourself 20 times. |
| Payback (Bronze) | Kill a Soldier by TK'ing a grenade or rocket back at them. |
| RIG Master (Silver) | Fully upgrade your RIG. |
| Share and Share Alike (Bronze) | Use the RIG to give an item to your Co-Op partner. |
| Shoot for the Moon (Gold) | Defeat the Moon. |
| Shootbang (Bronze) | Kill 30 Soldiers with head shots. |
| Slow Mo (Bronze) | Kill 50 enemies while they are in stasis. |
| Snow Crash (Bronze) | Reach Tau Volantis. |
| Space Ace (Bronze) | Shoot at least 70 targets during the ride to Tau Volantis. |
| Space Odyssey (Bronze) | Survive your first spacewalk. |
| Stranger in a Strange Land (Bronze) | Complete the Prologue. |
| Strapped (Bronze) | Craft a Weapon. |
| Survivalist (Silver) | Complete the game in Pure Survival Mode. |
| The Armorer (Bronze) | Collect all Circuits. |
| The Explorer (Bronze) | Complete all optional missions. |
| The Librarian (Bronze) | Collect all Logs. |
| The Professor (Bronze) | Collect all Artifacts. |
| There's Always Peng! (Silver) | Find Peng. |
| Together as One (Bronze) | Reassemble Rosetta. |
| Under a Buck (Bronze) | Shoot the deer head trophy in the Admiral's Quarters. |
| Weedkiller (Silver) | Kill 5 Cysts in the Biology Building with a single poison gas cloud. |
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