There are 38 Bronze Trophies, 7 Silver Trophies, 3 Gold Trophies, and 1 Platinum Trophy.
| Unlockable: | How to unlock: |
| A man with guts and honor (Bronze) | Reach the end of the descent on Mission 6 having killed all of the enemies |
| Absolutely crazy about it (Bronze) | Spend 50,000 Red Orbs |
| And welcome to Hell! (Gold) | Complete all missions on the Hell and Hell difficulty |
| And you are set free (Bronze) | Free half of the Lost Souls |
| Bring it on! (Bronze) | Slay 1,000 Demons |
| Cleaning up his Dad's mess (Bronze) | Defeat Mundus |
| Come on Puppy. Let's go! (Bronze) | Defeat your pursuer |
| Devils never cry (Gold) | Complete all missions on the Dante Must Die difficulty |
| Dude, the show's over! (Bronze) | Find all of the Keys |
| Every hero has a weakness (Bronze) | Complete Furnace of Souls without taking damage from the furnace |
| Fill your dark soul with light (Silver) | Free all of the Lost Souls |
| Flock off, feather-face! (Bronze) | Survive the encounter with the Tyrant |
| For Tony Redgrave (Bronze) | Kill 50 enemies using nothing but firearms |
| He's a demon too (Bronze) | Help Phineas retrieve his eye |
| Impressive (Bronze) | Slay 100 Demons |
| In the name of my father (Bronze) | Kill 100 enemies using nothing but Demon weapons |
| It's got to stay in the family (Bronze) | Acquire Arbiter |
| It's only the rain (Bronze) | Kill 10 enemies by pushing them into the Hurricane ride on Mission 1 |
| It's showtime. Come on! (Bronze) | Earn 1,500 Style Bonuses |
| It's time to finish this! (Bronze) | Help Vergil open the Vault |
| Jackpot! (Gold) | Complete all missions on the Nephilim difficulty with a SSS rank |
| Keeps getting better and better (Silver) | Gain a 100% completion rank on all missions (difficulty doesn't matter) |
| Let's rock, baby! (Bronze) | Upgrade Dante's health to maximum |
| Let's welcome chaos! (Bronze) | Open all of the Secret Doors |
| Looks like it's your lucky day (Bronze) | Complete a level without taking any damage |
| Looks like we have a winner (Silver) | Slay 5,000 Demons |
| More than just a few sparks (Bronze) | Acquire Revenant |
| No talking! (Bronze) | Acquire Aquila |
| Now my coat's all charred (Bronze) | Navigate the Sky Bridge on Mission 16 without hitting the lasers |
| One hell of a party! (Silver) | Complete all of the Secret Missions |
| Only kind of gift worth giving (Bronze) | Acquire the Angel Boost ability |
| Platinum Trophy (Platinum) | Collect all DmC Devil May Cry™ Trophies |
| Power... Give me more power! (Silver) | Purchase all of Dante's combat upgrades |
| Sensational! (Bronze) | Gain a SSS Style Rank during combat |
| Stylish! (Bronze) | Complete a mission with a SSS rank |
| The end? Don't bet on it (Silver) | Complete the final mission on Human, Devil Hunter or Nephilim difficulty |
| Thing drives me crazy (Bronze) | Acquire Osiris |
| This baby sure can pack a punch (Bronze) | Acquire Eryx |
| This is my kind of rain (Bronze) | Spend 10,000 Red Orbs |
| This is what I live for! (Bronze) | Complete all missions on the Heaven or Hell difficulty |
| This party's just getting crazy! (Bronze) | Complete 10 Secret Missions |
| Time to go to work guys! (Bronze) | Purchase your first upgrade |
| Too easy! (Silver) | Complete all missions on the Son of Sparda difficulty |
| Whatever, Lady (Bronze) | Defeat Mundus' spawn |
| Where does the time go? (Bronze) | Complete a level with 2 minutes or less on the clock |
| You are not a Human, are you? (Bronze) | Acquire the Devil Trigger ability |
| You can't handle it (Bronze) | Upgrade Dante's Devil Trigger to maximum |
| You'll never have her fire (Bronze) | Kill 100 enemies using nothing but Angel weapons |
| You're not going to shoot me (Bronze) | Acquire Kablooey |
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