Naturally, each have different strenghts and weaknesses, unless your playing on hardcore
then it really doesn't matter which you choose since they can't die.
In case you didn't know yet, you can have 2 followers 1 human(oid) and 1 non-human (the
game considers Lily and Raul as humanoids).
Arcade: you'll find him at the old mormon fort, if you have "confirmed bachelor" or a
speech of 75 or higher you can recruit him. Also if you have a good rep with the FoA he'll
join you, and apparently if your character has a low intelligence stat he'll join you out
of pity. However, if you are liked by the Legion he'll refuse no matter what.
His best stats are Energy Weapons, Medicine and Science. Naturally you'll want to give him
a well-conditioned energy weapon if you want to maximize his usefulness. He'll equip
pretty much any armor in the game (except maybe faction armor), since he's wearing low DT
clothes, so given good enough armor he can hold his own in a fight. His max HP is 245, and
i've noticed with his plasma defender (default weapon) he is a rather poor shot when it
comes to mantisses and other small creatures.
Also bear in mind, he'll leave you after his personal quest is completed, either he'll
wait for you for the final battle or leave the party altogether if you convince him that
his place is in freeside with the FoA, although the game says he's returned to the Old
Mormon Fort, he'll never actually go back there.
Boone: You'll find him in Novac, at the sniper's nest inside the dinosaur. He works the
night shift and will only speak with you then. You'll have to complete "one for my baby"
to get him to join you.
Boone's an ex-NCR 1st recon Sniper, naturally if you start killing NCRs he'll eventually
leave your party. He will wear NCR armor, any kind including the Desert Ranger armor. His
best skills are Guns, Melee and sneak. He is absolutely deadly with any sort of rifle but
especially the anti-material rifle, a sniper rifle or even a trail carbine. If given the
marksman carbine he'll often waste ammo, especially with high DT enemies such as
deathclaws, he'll use up 3-4 clips and still end up dead.
His max HP is 305.
Lily: You can find her in Jacobstown, during the quest "guess who i saw today" you have an
oppurtunity to recruit her. However, i don't know if you lose her if you complete the
quest. It would make sense that if you convince doctor henry to use the nightstalker to
further his research instead of Lily that you could keep her as a follower beyond the
completion of the quest, but i don't know for sure.
Lily's best skills are Melee and Sneak, she is very fast and agile during combat. She
won't equip any unique weapons such as Oh Baby, but will equip a super-sledge. She has a
max HP of 480. There is a bug where her vertibird sword will look like her assault
carbine, she'll swing the carbine like she would her sword.
Raul: You have to save him from captivity during the quest "crazy crazy crazy" on black
mountain. His best skills are Guns, Repair and Science. If you save him but do not recruit
him, he'll got back to his shack near nellis AFB, once he's there he can repair your gear
at 100% for a fee. He can wear any non-faction armor and he can be quite deadly with
revolvers especially the ranger sequoia, however the ammor for that gun is quite scarce, a
good alternative is the mysterious revolver. His max HP is 310.
Cass: She can be found at the Mojave Outpost, you'll have to start the quest "you can
depend on me" given to you at the crimson caravan HQ, and you'll have to convince her of
selling her caravan business, barter or speech check. If you didn't complete it already
you'll have to finish the quest given to you by the ranger there (clearing the roads)
before she tags along. If you have bad karma or worse she'll leave your party however.
Cass, like many others will wear whatever non-faction armor you give her, she is also very
deadly with a hunting shotgun especially the dinner bell. She is moderately good with a
marksman carbine as well as a trail carbine but she isn't the most accurate shot, which is
why the shotgun suits her best. Her best skills are, obviously Guns, melee and sneak. Her
max HP is 285, if you complete her quest and she receives the calm heart perk her max HP
will be 335. During "birds of a feather" if you turn Cass in to the Van Graffs they'll
kill her, just a heads-up.
Veronica: She can be found at the 188 trading post, no pre-requirements to have her join
you, but if you are disliked by the BoS she'll leave your party.
Her best skills are Unarmed, Science and Energy Weapons. She is bugged though, and the
lastest patch do not fix it. She will NOT level during the game, she'll remain at level 12
so she will be easily killed at higher levels. She can be quite effective with a ballistic
fist, she'll prefer that to the displacer glove but not the unique Pushy. She will wear
BoS power armor, but no other faction armor. She can be effective with high powered energy
weapons such as the multiplas rifle or the gauss rifle but she's is best suited for close
ED-E: can be found in Primm, once repaired he'll join you, he is one of two non-human
companions. ED-E is rather weak, he won't kill many enemies easily nor will he survive an
encouter with tough enemies, but if you couple his "enhanced sensors" perk with boone's
"spotter" perk you can have a very deadly "sniper" group. ED-E also amusingly will play
"combat" music to warn you when he engages in combat, since he cannot speak. Once his
quest will be completed he will be either tougher or more powerful, but will still take at
least 2 shots to kill a lowly coyote, and will still get dismantled by the tougher
Rex: you'll find him in freeside, at the king's school of impersonation. You'll have to
talk to the King about his dog, and speak with Julie Farkas at the old mormon fort to
learn Rex can be cured, then you'll have Rex as a follower indefinetely. You can choose
one of 3 brains to replace his dying one. Rey's brain will grant him a damage increase,
rey is old lady gibson's dog, you'll have to buy it from her. Violetta's brain will grant
him a speed increase, violetta is a fiend's dog, you'll have to kill her for it. Lupa's
brain grants him an HP increase, Lupa can be found at the fort you'll have to kill her for
Also, sometimes NCR guard dogs will drop their brains, but this has no benefit.
Rex can be a very useful companion, he is also one of two non-human companions. He can
easily take out small critters that you rather not waste ammo on, such as mantisses etc.
His very high perception will have him run off to kill enemies before you can spot them.
Rex can hold his own against weak-to-normal enemies but from giant radscoprion and
stronger he'll get killed in no time. His perk is also useful, you can detect items by
IMO, there's no absolute "best", it depends on what type of character you play as. If you
play as a sniper then boone and ED-E will definetely be best suited for you. If you play a
"guns blazing" type then Lily's and Rex's speed might be best suited. If you play as a BoS
member, then the obvious choice would be Vero and ED-E, same as with an NCR ranger
playthrough boone and rex would be best. Many different things factor into who are the
best companions, it's almost entirely subgjective.