There are 47 Bronze Trophies, 22 Silver Trophies, 6 Gold Trophies, and 1 Platinum Trophy.
| Unlockable: | How to unlock: |
| Ain't That a Kick in the Head (Bronze) | Completed Ain't That a Kick in the Head. |
| All or Nothing (Bronze) | Completed All or Nothing. |
| Arizona Killer (Bronze) | Completed Arizona Killer. |
| Artful Pocketer (Bronze) | Pick 50 pockets. |
| Assemble Your Crew (Bronze) | Recruited Dean Domino, Christine and Dog. |
| Blast Mastery (Bronze) | Cause 10,000 damage with Energy Weapons. |
| Caravan Master (Silver) | Win 30 games of Caravan. |
| Cardiac Arrest! (Bronze) | Recovered X-13 cardiac regulator sneaky suit! |
| Cash Out (Silver) | Confronted Father Elijah in the Sierra Madre's Vault. |
| Combat Veteran (Silver) | Completed any three Gun Runners' Arsenal (GRA) two star (**) Challenges. |
| Come Fly With Me (Bronze) | Completed Come Fly With Me. |
| Condemned to repeat it (Bronze) | Decided the fate of all the Divide dwellers. |
| Crafty (Bronze) | Craft 20 items. |
| Curios and Relics (Bronze) | Caused 10,000 damage with unique Mojave Wasteland weapons. |
| Desert Survivalist (Bronze) | Heal 10,000 points of damage with food. |
| Double Down (Bronze) | Play 10 hands of Blackjack. |
| ED-Ecated (Bronze) | Found all of ED-E's upgrades in the Divide. |
| Eureka! (Bronze) | Completed Eureka! |
| For the Republic (Silver) | Completed For the Republic. |
| G.I. Blues (Bronze) | Completed G.I. Blues. |
| Globe Trotter (Silver) | Discover all snow globes. |
| Hack the Mojave (Bronze) | Hack 25 terminals. |
| Hardcore (Gold) | Play the game from start to finish in Hardcore Mode. |
| Having a Ball (Bronze) | Completed the Sierra Madres Gala Event. |
| Hometown Hero (Gold) | Completed Lonesome Road. |
| In a Foreign Land (Bronze) | Scouted the Zion Valley for signs of the White Legs. |
| Jury Rigger (Bronze) | Repair 30 items. |
| Know When to Fold Them (Bronze) | Win 3 games of Caravan. |
| Lead Dealer (Bronze) | Cause 10,000 damage with Guns. |
| Little Wheel (Bronze) | Play 10 spins of Roulette. |
| Love the Bomb (Bronze) | Cause 10,000 damage with Explosives. |
| Make up your Mind (Bronze) | Made up your mind...about your brain. |
| Making Friends (Silver) | Reactivated all of the Sink's robotic assistants. |
| Master of the Arsenal (Silver) | Caused 10,000 damage with Gun Runners' Arsenal (GRA) Weapons. |
| Master of the Mojave (Silver) | Discover 125 locations. |
| May my Hand Forget its Skill (Gold) | Evacuated Zion. |
| Mod Machine (Bronze) | Install 20 weapon mods. |
| New Kid (Bronze) | Reach 10th level. |
| New Vegas Samurai (Bronze) | Cause 10,000 damage with Melee Weapons. |
| No Gods, No Masters (Bronze) | Completed No Gods, No Masters. |
| No Tumbler Fumbler (Bronze) | Pick 25 locks. |
| O Daughter of Babylon (Silver) | Crushed the White Legs. |
| Ol' Buddy Ol' Pal (Bronze) | Recruit any companion. |
| Old-Tyme Brawler (Bronze) | Cause 10,000 damage with Unarmed weapons. |
| One Armed Bandit (Bronze) | Play 10 spins of Slots. |
| Outsmarted (Gold) | Completed Old World Blues. |
| Outstanding Orator (Bronze) | Make 50 Speech challenges. |
| Platinum Trophy (Platinum) | Collect all other 50 Trophies for this Trophy. |
| Pros Only (Gold) | Complete any three Gun Runners' Arsenal (GRA) three star (***) Challenges. |
| Render Unto Caeser (Silver) | Completed Render Unto Caeser. |
| Restore Our Fortunes (Silver) | Resupplied Daniel and the Sorrows. |
| Return to Sender (Bronze) | Completed Return to Sender. |
| Ring-a-Ding-Ding (Silver) | Completed Ring-a-Ding-Ding. |
| Rocket's Red Glare (Silver) | Acquired all upgrades for the Divide's signature weapon. |
| Safety Deposit Box (Gold) | Trapped Father Elijah in the Sierra Madre's Vault. |
| Sierra Souvenir Aficionado (Silver) | Collected 500 Sierra Madre Chips. |
| Spinal-Tapped! (Bronze) | Recovered X-8 vertabrae-pulse-de-sensitizer frequency! |
| Stim-ply Amazing (Bronze) | Heal 10,000 points of damage with Stimpaks. |
| Talent Pool (Bronze) | Completed Talent Pool. |
| That Lucky Old Sun (Bronze) | Completed That Lucky Old Sun. |
| The Boss (Silver) | Reach 30th level. |
| The Courier Who Broke the Bank (Silver) | Get banned from all the Strip's casinos. |
| The House Always Wins (Silver) | Completed The House Always Wins. |
| The Legend of the Star (Bronze) | Completed The Legend of the Star. |
| The Whole Gang's here (Silver) | Recruit all companions. |
| They Went That-a Way (Silver) | Completed They Went That-a Way. |
| Up and Comer (Silver) | Reach 20th level. |
| Up to the Challenge (Bronze) | Complete any three Gun Runners' Arsenal (GRA) one star (*) Challenges. |
| Veni, Vidi, Vici (Bronze) | Completed Veni, Vidi, Vici. |
| Volare! (Bronze) | Completed Volare! |
| Walker of the Mojave (Bronze) | Discover 50 locations. |
| Warhead Hunter (Silver) | Detonated all of the warheads in the Divide. |
| When We Remembered Zion (Bronze) | Arrived at Zion. |
| Wild Card (Silver) | Completed Wild Card. |
| You Run Barter Town (Bronze) | Sell 10,000 caps worth of goods. |
| You'll Know It When It Happens (Bronze) | Completed You'll Know It When It Happens. |
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