There are 40 Bronze Trophies, 6 Silver Trophies, 3 Gold Trophies, and 1 Platinum Trophy.
| Unlockable: | How to unlock: |
| 4-Point Line (Bronze) | Pull off a successful 4-point play with any player, in a non-simulated game. |
| A 2K to Call My Own (Bronze) | Create a My2K Account. |
| Another Day, Another Win (Bronze) | Win 5 NBA Today matchups. |
| Back to Back to Back (Bronze) | Win 3 Versus matches in a row. |
| Birthday (Bronze) | Create-a-Player. |
| Block Party (Bronze) | Record 10 or more blocks with any team, in a non-simulated game. |
| Buzzer Beater (Bronze) | Make a game winning shot with no time left on the clock, in a non-simulated game. |
| Check! (Bronze) | Complete all 3 in-game objectives in My Player mode. |
| Come Fly with Me (Bronze) | Purchase Michael Jordan's dunk package (His Airness) in My Player mode. |
| Dawn of an Era (Bronze) | Get drafted as a lottery pick in the NBA draft in My Player mode. |
| Don't Hate the Player (Gold) | Win the championship in an Online Association. |
| Dub-Dub (Bronze) | Record two double doubles with any teammates, in a non-simulated game. |
| Five by Five (Bronze) | Record 5 or more in 5 different stats with any player in a non-simulated game. |
| G Performance (Bronze) | Score at least 48 points with Kevin Durant to set a new career high, in a non-simulated game. |
| G Prime (Silver) | End the 1st period with a 15 point lead or greater on the Hall of Fame difficulty setting. |
| G Recovery (Bronze) | Play an entire game using manual substitutions, in a non-simulated game. |
| Giveth and Taketh Away (Bronze) | Record 10 or more rebounds and assists with any player, in a non-simulated game. |
| Hamilton (Bronze) | Win 10 Versus matches total. |
| Hey Mr. DJ (Bronze) | Create a 2K Beats Playlist. |
| Hold the Fat Lady (Bronze) | Start the 4th period losing by 10 or more points and win with any team, in a non-simulated game. |
| Home Court (Silver) | Earn the NBA's best record in The Association mode (at least 30 games played). |
| I'm Worth It (Silver) | Land a contract that pays at least $10M per season in My Player mode. |
| Immortality (Gold) | Make the Hall of Fame in My Player mode. |
| It's Better to Give (Bronze) | Share any file type through 2K Share. |
| It's Raining (Bronze) | Make 15 or more 3-pointers with any team, in a non-simulated game. |
| Left My Mark (Bronze) | Complete 10 of the NBA's Greatest challenges. |
| Lincoln (Bronze) | Win 5 Versus matches total. |
| Made My Name (Bronze) | Complete 5 of the NBA's Greatest challenges. |
| Men of Steal (Bronze) | Record 10 or more steals with any team, in a non-simulated game. |
| Money Bags (Bronze) | Purchase 3,000 skill points in a single transaction in My Player mode. |
| My All-Star (Bronze) | Be named an NBA All-Star in My Player mode. |
| My Big Eight-O (Bronze) | Earn an 80 overall rating in My Player mode. |
| My Every Day Player (Bronze) | Become a starter in the NBA in My Player Mode. |
| My Player of the Game (Bronze) | Be named Player of the Game (in an NBA game) in My Player mode. |
| NBA Cares (Bronze) | Make a donation to the NBA Cares global community outreach initiative in My Player mode. |
| Not Your Father's Association (Bronze) | Join an Online Association. |
| Shooting Star (Bronze) | Win the MVP award in NBA: Creating a Legend mode. |
| Smothering (Bronze) | Hold the opposing team's FG% below 40% with any team, in a non-simulated game. |
| Sprite Slam Cam (Bronze) | Get the Sprite Slam Cam replay after a dunk with LeBron James. |
| Streaking (Silver) | Win 5 games in a row in The Association mode (playing all 5 games). |
| Swat and Swipe (Bronze) | Record at least 5 blocks and 5 steals with any team, in a non-simulated game. |
| The Closer (Bronze) | Hold the opposing team to 0 points in the final two minutes of regulation, in a non-simulated game. |
| The Sum of Its Parts (Bronze) | Play a Team Up Game. |
| The Whole Shebang (Platinum) | Earn every trophy in NBA 2K12. |
| This One Counts (Bronze) | Win one online Versus match. |
| Ticker Tape (Gold) | Win an NBA Championship in The Association mode (playing every playoff game). |
| Trip-Dub (Bronze) | Record a triple double with any player, in a non-simulated game. |
| Wire to Wire (Bronze) | Do not allow your opponent to lead the game at any point with any team, in a non-simulated game. |
| Wrote My Legend (Silver) | Complete all 15 of the NBA's Greatest challenges. |
| You're Officially Hot (Silver) | Win 5 Versus matches in a row. |
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