When you fight Doc Oc for the last time, save up your Spidey Sense energy. When
it gets too full or half-way, let him get close and active it. This will help you defeat
him without losing health. Note: If you can get good hits on him when three of his
four arms are down, you will take little damage if you are careful.

When facing Doc Ock in the final battle, stand your ground in a corner and let him
approach you. When he arrives, beware of his tentacles. Dodge them one by one
pressing B when Spider- Man's head flashes, then respond to each dodge by
pressing Y and shooting a web at the Doc's tentacles to bind them to the wall or
the ground. When all four tentacles are bound to either the ground or the wall, run
towards the Doc by holding L then pressing X, performing an uppercut which sends
the Doc in the air. Then, hold and release A and continue to press X rapidly. When
the Doc falls to the ground, continue to perform combos to him by pressing X, but
beware of his tentacles. Doc Ock will use them to throw you repeatedly. Web out
of there after one combo and move to another corner and repeat the process until
the Doc is defeated.