Accomplish the indicated achievement to get the corresponding number of Gamerscore points:
| Unlockable: | How |
| Bought a Slot (5 points) | Buy one Plasmid or Tonic Slot at a Gatherer's Garden. |
| Max Plasmid Slots (10 points) | Fully upgrade to the maximum number of Plasmid Slots. |
| Upgraded a Weapon (10 points) | Upgrade any weapon at a Power to the People Station. |
| Fully Upgraded a Weapon (10 points) | Install the third and final upgrade to any of your weapons. |
| All Weapon Upgrades (20 points) | Find all 14 Power to the People weapon upgrades in the game. |
| Prolific Hacker (20 points) | Successfully hack at least one of every type of machine. |
| Master Hacker (20 points) | Hack 30 machines at a distance with the Hack Tool. |
| First Research (5 points) | Research a Splicer with the Research Camera. |
| One Research Track (20 points) | Max out one Research Track. |
| Research Master (20 points) | Max out research on all 9 research subjects. |
| Grand Daddy (25 points) | Defeat 3 Big Daddies without dying during the fight. |
| Master Gatherer (30 points) | Gather 600 ADAM with Little Sisters. |
| Fully Upgraded a Plasmid (10 points) | Fully upgrade one of your Plasmids to the level 3 version at a Gatherer's Garden. |
| All Plasmids (20 points) | Find or purchase all 11 basic Plasmid types. |
| Trap Master (15 points) | Kill 30 enemies using only Traps. |
| Master Protector (15 points) | Get through a Gather with no damage and no one getting to the Little Sister. |
| Big Spender (15 points) | Spend 2000 dollars at Vending Machines. |
| Dealt with Every Little Sister (50 points) | Either Harvest or Save every Little Sister in the game. |
| Against All Odds (30 points) | Finish the game on the hardest difficulty level. |
| Big Brass Balls (25 points) | Finish the game without using Vita-Chambers. |
| Rapture Historian (40 points) | Find 100 audio diaries. |
| Unnatural Selection (10 points) | Score your first kill in a non-private match. |
| Welcome to Rapture (10 points) | Complete your first non-private match. |
| Disgusting Frankenstein (10 points) | Become a Big Daddy for the first time in a non-private match. |
| "Mr. Bubbles - No!" (20 points) | Take down your first Big Daddy in a non-private match. |
| Mother Goose (20 points) | Save your first Little Sister in a non-private match. |
| Two-Bit Heroics (10 points) | Complete your first trial in a non-private match. |
| Parasite (10 points) | Achieve Rank 10. |
| Little Moth (20 points) | Achieve Rank 20. |
| Skin Job (20 points) | Achieve Rank 30. |
| Choose the Impossible (50 points) | Achieve Rank 40. |
| Proving Grounds (20 points) | Win your first non-private match. |
| Man About Town (10 points) | Play at least one non-private match on each multiplayer map. |
