| Unlockable: | How to unlock: |
| Alive Without Breath (10) | You took possession of a fish |
| An Unfortunate Accident (10) | You killed Morgan Pendleton with steam |
| Art Dealer (50) | You collected all the Sokolov paintings |
| Back Home (10) | You grabbed a live grenade and threw it back, killing an attacker |
| Big Boy (20) | You killed a tallboy using only your sword |
| Bodyguard (10) | You protected Callista's uncle, Captain Geoff Curnow |
| Capturing Genius and Madness (10) | You abducted Anton Sokolov, Royal Physician |
| Child Care (10) | You located Lady Emily Kaldwin, heir to the throne |
| Clean Hands (100) | You completed the game without killing anyone |
| Cleaner (10) | You fought 5 enemies at once and none of them survived |
| Creepy Crawly (10) | You used a rat tunnel |
| Dishonored (5) | You escaped Coldridge Prison |
| Dunwall in Chaos (50) | You completed the game in high chaos |
| Excommunication (5) | You eliminated High Overseer Campbell |
| Faceless (20) | After escaping Coldridge Prison, you completed a mission without alerting anyone |
| Food Chain (10) | You assassinated an assassin |
| Gentleman Caller (10) | You completed all the Granny Rags side missions |
| Ghost (30) | You completed all missions after the prologue, alerting or killing no one but key targets |
| Harm's Way (10) | You caused 5 unintentional suicides |
| Hornets' Nest (20) | You killed 4 enemies in less than 1 second using the crossbow |
| Inhabitant (10) | You stayed in possession of others for most of a 3 minute period |
| Just Dark Enough (50) | You completed the game in low chaos |
| King of the World (10) | You reached the top of Kaldwin's Bridge |
| Lights Out (10) | You deactivated at least 5 security systems on Kingsparrow Island |
| Long Live the Empress (10) | You saved Empress Emily Kaldwin |
| Manipulator (10) | You made others kill 5 of their own allies |
| Merchant of Disorder (20) | You acquired 15 equipment upgrades |
| Mercy is the Mark (10) | You spared Daud's life |
| Mostly Flesh and Steel (50) | You finished the game without purchasing any supernatural powers or enhancements, besides Blink |
| Occultist (20) | You collected 10 bone charms |
| Poetic Justice (30) | You neutralized all key targets using indirect means |
| Political Suicide (10) | You brought about the Lord Regent's fall from grace by broadcasting his crimes |
| Razor Rain (10) | You killed 5 characters with Drop Assassination |
| Regicide (10) | You assassinated the Lord Regent, Hiram Burrows |
| Resolution (100) | You completed the game |
| Rogue (10) | You assassinated 10 unaware enemies |
| Shadow (30) | You completed all missions after the prologue without alerting anyone |
| Specter (20) | After escaping prison, you completed a mission, not alerting anyone and killing less than 5 people |
| Speed of Darkness (10) | You traveled 30 meters in less than 1 second |
| Street Conspiracy (10) | You completed all the Slackjaw side missions |
| Surgical (30) | You played from the first mission through Kaldwin's Bridge killing fewer than 10 characters |
| Tempest (20) | You killed 6 enemies in less than 1 second |
| The Art of the Steal (10) | You got the Art Dealer's safe combination for Slackjaw, but robbed the safe first |
| The Escapist (10) | After Coldridge Prison, you eluded 5 pursuers at once without killing them or leaving the map |
| Thief (20) | You pickpocketed items worth a total of 200 coins |
| This Is Mine (10) | You recovered your belongings |
| Vanished (10) | You escaped prison and navigated the sewers undetected |
| Versatile (20) | You killed characters with each weapon and offensive gadget |
| Wall of Sparks (10) | You killed an enemy with the Wall of Light |
| Well Mannered (10) | You completed the Boyle Estate mission without spoiling the party |
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