| Unlockable: | How to unlock: |
| A man with guts and honor (10) | You reached the end of the descent on Mission 6 having killed all of the enemies |
| Absolutely crazy about it (20) | You have Spent 50,000 Red Orbs |
| And welcome to Hell! (100) | Completed all missions on Hell and Hell difficulty |
| And you are set free (10) | You have found half of the Lost Souls |
| Bring it on! (20) | You have slayed 1,000 Demons |
| Cleaning up his Dad's mess (20) | You have defeated Mundus |
| Come on Puppy. Let's go! (20) | You have defeated the Hunter |
| Devils never cry (100) | Completed all missions on the Dante Must Die difficulty |
| Dude, the show's over! (10) | You have found all 21 Keys |
| Every hero has a weakness (10) | You completed Furnace of Souls without taking damage from the furnace |
| Fill your dark soul with light (20) | You have found all of the Lost Souls |
| Flock off, feather-face! (20) | You have defeated the Tyrant |
| For Tony Redgrave (10) | You killed 50 enemies using nothing but firearms |
| He's a demon too (10) | You helped Phineas by retrieving his eye |
| Impressive (10) | You have slayed 100 Demons |
| In the name of my father (10) | You killed 100 enemies using nothing but Demon weapons |
| It's got to stay in the family (10) | You have acquired Arbiter |
| It's only the rain (10) | You Killed 10 enemies by pushing them into the Hurricane ride |
| It's showtime. Come on! (20) | You earned 1,500 Style Bonuses |
| It's time to finish this! (10) | You helped Vergil open the Vault |
| Jackpot! (80) | Completed all missions on the Nephilim difficultly with a SSS rank |
| Keeps getting better and better (40) | You have been awarded a 100% completion rank on all missions |
| Let's rock, baby! (10) | You have upgraded Dante's health to maximum |
| Let's welcome chaos! (10) | You have opened all 21 Secret Doors |
| Looks like it's your lucky day (10) | You completed a level without taking any damage |
| Looks like we have a winner (30) | You have slayed 5,000 Demons |
| More than just a few sparks (10) | You have acquired Revenant |
| No talking! (20) | You have acquired Aquila |
| Now my coat's all charred (10) | You navigated the Sky Bridge without hitting the lasers |
| One hell of a party! (50) | You have completed all of the Secret Missions |
| Only kind of gift worth giving (10) | You have acquired the Angel Boost ability |
| Power... Give me more power! (20) | You have purchased all of Dante's combat upgrades |
| Sensational! (10) | You gained a SSS Style Rank during combat |
| Stylish! (10) | Completed a mission with a SSS rank |
| The end? Don't bet on it (40) | You defeated Vergil on any difficulty |
| Thing drives me crazy (10) | You have acquired Osiris |
| This baby sure can pack a punch (20) | You have acquired Eryx |
| This is my kind of rain (10) | You have spent 10,000 Red Orbs |
| This is what I live for! (10) | Completed all missions on Heaven Or Hell difficulty |
| This party's just getting crazy! (20) | You have completed 10 of the Secret Missions |
| Time to go to work guys! (10) | You purchased your first upgrade |
| Too easy! (40) | Completed all missions on the Son of Sparda difficulty |
| Whatever, Lady (20) | You have defeated Mundus' spawn |
| Where does the time go? (10) | You completed a level in 2 minutes or less |
| You are not a Human, are you? (10) | You have acquired the Devil Trigger ability |
| You can't handle it (10) | You have upgraded Dante's Devil Trigger to maximum |
| You'll never have her fire (10) | You killed 100 enemies using nothing but Angel weapons |
| You're not going to shoot me (10) | You have acquired Kablooey |
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