There are 46 achievements with a total of 1050 gamerscore.
| Unlockable: | How to unlock: |
| Medal of Honor (100 gs) | Complete 1 Mass Effect Playthrough on any setting |
| Medal of Heroism (25 gs) | Complete Feros |
| Distinguished Service Medal (25 gs) | Complete Eden Prime |
| Council Legion of Merit (25 gs) | Complete Virmire |
| Honorarium of Corporate Service (25 gs) | Complete Noveria |
| Long Service Medal (25gs) | Complete 2 Mass Effect Playthroughs on any setting |
| Distinguished Combat Medal (25 gs) | Complete 1 Mass Effect playthrough on the Hardcore difficulty setting. Do not change the setting. |
| Medal of Valor (50 gs) | Complete 1 Mass Effect playthrough on the Insanity difficulty setting. Do not change the setting. |
| Pistol Expert (10 gs) | Register 150 Pistol Kills |
| Shotgun Expert (15 gs) | Register 150 Shotgun Kills |
| Assault Rifle Expert (15 gs) | Register 150 Assault Rifle Kills |
| Sniper Expert (15 gs) | Register 150 Sniper Rifle Kills |
| Lift Mastery (15 gs) | Use biotic Lift 75 times |
| Throw Mastery (15 gs) | Use biotic Throw 75 times |
| Warp Mastery (15 gs) | Use biotic Warp 75 times |
| Singularity Mastery (15 gs) | Use biotic Singularity 75 times |
| Barrier Mastery (15 gs) | Use biotic Barrier 75 times |
| Stasis Mastery (15 gs) | Use biotic Stasis 75 times |
| Damping Specialist (15 gs) | Use Damping Field 75 times |
| AI Hacking Specialist (15 gs) | Use AI Hacking 75 times |
| Overload Specialist (15 gs) | Use Shield Overload 75 times |
| Sabotage Specialist (15 gs) | Use Sabotage 75 times |
| First Aid Specialist (15 gs) | Use medi-gel 150 times |
| Neural Shock Specialist (15 gs) | Use Neural Shock 75 times |
| Scholar (25 gs) | Find all primary Alien: Council Races, Extinct Races and Non-Council Races codex entries |
| Completionist (25 gs) | Complete the majority of the game |
| Tactician (25 gs) | Complete playthrough with shield damage greater than health damage |
| Medal of Exploration (50 gs) | Land on an uncharted world |
| Rich (25 gs) | Exceed 1,000,000 Credits |
| Dog of War (25 gs) | Register 150 organic enemy kills |
| Geth Hunter (25 gs) | Register 250 synthetic enemy kills |
| Soldier Ally (20 gs) | Complete the majority of the game with the Alliance soldier squad member |
| Sentinel Ally (20 gs) | Complete the majority of the game with the Alliance sentinel squad member |
| Krogan Ally (20 gs) | Complete the majority of the game with the krogan squad member |
| Turian Ally (20 gs) | Complete the majority of the game with the turian squad member |
| Quarian Ally (20 gs) | Complete the majority of the game with the quarian squad member |
| Asari Ally (20 gs) | Complete the majority of the game with the asari squad member |
| Power Gamer (20 gs) | Reach 50th level with one character |
| Extreme Power Gamer (50 gs) | Reach 60th level with one character |
| Renegade (15 gs) | Accumulate 75% of total Renegade points |
| Paragon (15 gs) | Accumulate 75% of total Paragon points |
| Paramour (10 gs) | Complete any romance subplot |
| Spectre Inductee (15 gs) | Become a Spectre |
| Charismatic (10 gs) | Use Charm or Intimidate to resolve an impossible situation |
| Search and Rescue (10 gs) | Locate Dr. T'soni in the Artemis Tau cluster |
| Colonial Savior (50 gs) | Complete the Bring Down the Sky mission. |
