Accomplish the indicated achievement to get the corresponding number of Gamerscore points:
| Unlockable: | How to unlock: |
| Revenge Revisited (60 points) | Complete Story Mode on hard difficulty. |
| Endless Hunger (10 points) | Consume 200 characters to boost your health. |
| Trail Of Corpses (30 points) | Kill 53,596 infected. |
| Wrecking Yard (20 points) | Destroy 2,000 vehicles. |
| Misconception (20 points) | Destroy 25 Infected Water Towers before they hatch. |
| Brain Trust (20 points) | Complete all Consume Events. |
| Streetwise (50 points) | Collect all Landmark collectibles scattered across New York City. |
| Polymath (40 points) | Collect all Hint Collectibles scattered across New York City. |
| Half-Truths (10 points) | Complete a mission without causing a single Military Alert. |
| Mankind Is Your Mask (40 points) | Complete 3 missions without causing a single Military Alert. |
| The Butcher (30 points) | Kill 50 characters in 5 seconds. |
| Return Fire (10 points) | Catch any object tossed by a Hydra; and throw it back. |
| Gunning (10 points) | Destroy 20 Helicopters in a single Helicopter flight. |
| Cleanup (10 points) | Kill 15 characters with a single Whipfist attack. |
| The First Thread (10 points) | Unlock the Web of Intrigue. |
| Self-Deception (20 points) | Discover what happened to Alex Mercer through the Web of Intrigue. |
| Web Of Knowledge (60 points) | Acquire all nodes of the Web of Intrigue. |
| It's Him! (10 points) | Patsy 5 military personnel. |
| In Plain Sight (10 points) | Evade 10 strike teams. |
| Infiltrator (20 points) | Infiltrate 10 Military Bases disguised as a Commander. |
| Threat Elevated (20 points) | Destroy 25 strike teams. |
| Repossession (10 points) | Seize 50 vehicles from enemy hands. |
| SME (20 points) | Gain the ability to drive and fly all vehicles. |
| Surface-To-Air (10 points) | Shoot down 50 helicopters while driving armor. |
| Evolutionary Step (10 points) | Use the Upgrade Menu to acquire an Upgrade. |
| Unnatural Selection (40 points) | Acquire all available upgrades. |
| The Cleaner (20 points) | Destroy 10 Military Bases or Infected Hives in New York City. |
| In The Web (20 points) | Consume 50 Web Targets. |
| Au (40 points) | Achieve a rating of Gold or better in all Events. |
| Nice Guy (40 points) | Complete the game while consuming 10 Civilians or fewer. |
| Hard To Kill (60 points) | Complete Story Mode in any difficulty without dying. |
| Speed Bumps (20 points) | Run over 500 characters in a single tank. |
| Pt (60 points) | Achieve a Platinum Medal in all Events. |
| Secret achievement (10 points) | Unknown. |
| Secret achievement (10 points) | Unknown. |
| Secret achievement (20 points) | Unknown. |
| Secret achievement (20 points) | Unknown. |
| Secret... |
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