| Unlockable: | How to unlock: |
| All Rounder (20) | Beat 100,000 points in a Combo Arrangement |
| Art + Functionality (30) | Collect all guitars |
| Batter Up (5) | Play the Guitarcade game: Big Swing Baseball |
| Beat Harmonics (20) | Beat 1,000,000 points in the Guitarcade game: Harmonically Challenged |
| Beneficial Friends (20) | Play multiplayer with 2 guitars |
| Better Than An Encore? (20) | Qualify for a Double Encore |
| Cente-beater (10) | Beat a 100 Note Streak |
| Challenge Harmonics (5) | Play the Guitarcade game: Harmonically Challenged |
| Chordinated (20) | Beat 100,000 points in a Chord Arrangement |
| D-licious (10) | Use the Tuner to tune to Drop-D |
| Duck Hunter (5) | Play the Guitarcade game: Ducks |
| Ducks x 6 (5) | Play the Guitarcade game: Super Ducks |
| Elite Guitarist (60) | Reach Rank 9 |
| Fret Fast (20) | Beat 10,000,000 points in the Guitarcade game: Ducks |
| Furious Plucker (20) | Beat 5,000,000 points in the Guitarcade game: Quick Pick Dash |
| Giant! (20) | Beat 2,000,000 points in the Guitarcade game: Big Swing Baseball |
| Guitardead (20) | Beat 1,000,000 points in the Guitarcade game: Dawn of the Chordead |
| Half-K (25) | Beat a 500 Note Streak |
| Happy Shopper (5) | Visit the shop |
| Hear Me Now (10) | Use the Amp |
| International Headliner (40) | Reach Rank 8 |
| International Support Act (40) | Reach Rank 7 |
| Just Awesome (40) | Beat a 750 Note Streak |
| Just Singing? (10) | Using a mic, sing along and achieve Nice Singing |
| Just Super! (20) | Beat 150,000,000 points in the Guitarcade game: Super Ducks |
| Local Headliner (10) | Reach Rank 4 |
| Local Support Act (10) | Reach Rank 3 |
| My 1st Encore (10) | Qualify for an Encore |
| My 1st Gig (5) | Play an Event |
| National Headliner (20) | Reach Rank 6 |
| National Support Act (20) | Reach Rank 5 |
| New Act (5) | Reach Rank 2 |
| No Dischord (20) | Beat a 25 Chord Streak |
| OK, I Learned (20) | Beat 200,000 points in Master Mode |
| Rocksmith (100) | Reach Rank 11 |
| Scales Owned (20) | Beat 50,000,000 points in the Guitarcade game: Scale Runner |
| Singles Rock (20) | Beat 100,000 points in a Single Note Arrangement |
| Slide Puzzle (5) | Play the Guitarcade game: Super Slider |
| Slide to Victory (20) | Beat 15,000,000 points in the Guitarcade game: Super Slider |
| Solo Foundations (5) | Play the Guitarcade game: Scale Runner |
| Stage Ready (40) | Complete a Master Event |
| Strummer (5) | Beat a 5 Chord Streak |
| Super Elite Guitarist (60) | Reach Rank 10 |
| The Basics (5) | Complete Soundcheck (Reach Rank 1) |
| The One With Zombies (5) | Play the Guitarcade game: Dawn of the Chordead |
| The Rocksmith Method (20) | Earn all Bronze Technique Medals |
| Tone is My Avatar (10) | Create and save a custom tone |
| Tone Peddler (30) | Collect 50 effects pedals |
| Tutorials My Axe (30) | Earn all Gold Technique Medals |
| Where Rainbows Come From (5) | Play the Guitarcade game: Quick Pick Dash |
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